Publikationen des Jahres 2020

Afridi, S.Q., H. Moeini, B. Kalali, J.M. Wettengel, O. Quitt, R. Semper, M. Gerhard, U. Protzer, and D. Hoffmann. 2020.

Quantitation of norovirus-specific IgG before and after infection in immunocompromised patients.

Braz J Microbiol. 51:183-187.

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Aguilar-Pimentel, J.A., Y.L. Cho, R. Gerlini, J. Calzada-Wack, M. Wimmer, P. Mayer-Kuckuk, T. Adler, C.B. Schmidt-Weber, D.H. Busch, H. Fuchs, V. Gailus-Durner, M. Ollert, M. Hrabe de Angelis, C. Ohlsson, M. Poutanen, R. Teperino, and L. Strauss. 2020.

Increased estrogen to androgen ratio enhances immunoglobulin levels and impairs B cell function in male mice.

Sci Rep. 10:18334.

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Andra, I., H. Ulrich, S. Durr, D. Soll, L. Henkel, C. Angerpointner, J. Ritter,  S. Przibilla, H. Stadler, M. Effenberger, D.H. Busch, and M. Schiemann. 2020.

An Evaluation of T-Cell Functionality After Flow Cytometry Sorting Revealed p38 MAPK Activation.

Cytometry A. 97:171-183.

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Bajic, D., A. Niemann, A.K. Hillmer, R. Mejias-Luque, S. Bluemel, M. Docampo, M.C. Funk, E. Tonin, M. Boutros, B. Schnabl, D.H. Busch, T. Miki, R.M. Schmid, M.R.M. van den Brink, M. Gerhard, and C.K. Stein-Thoeringer. 2020.

Gut microbiota derived propionate regulates the expression of Reg3 mucosal lectins and ameliorates experimental colitis in mice.

J Crohns Colitis. 2020 Oct 5;14(10):1462-1472. doi: 10.1093/ecco-jcc/jjaa065.(link is external)

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Barnowski, C., G. Ciupka, R. Tao, L. Jin, D.H. Busch, S. Tao, and I. Drexler. 2020.

Efficient Induction of Cytotoxic T Cells by Viral Vector Vaccination Requires STING-Dependent DC Functions.

Front Immunol. 11:1458.

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Berkefeld, A., F.K. Berger, B.C. Gartner, N. Wantia, A. Prinzing, K.L. Laugwitz, D.H. Busch, and K. Rothe. 2020.

Clostridioides (Clostridium) difficile Pacemaker Infection.

Open Forum Infect Dis. 7:ofaa487.

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Blechner, C., L. Becker, H. Fuchs, B. Rathkolb, C. Prehn, T. Adler, J. Calzada-Wack, L. Garrett, V. Gailus-Durner, F. Morellini, S. Conrad, S.M. Holter, E. Wolf, T. Klopstock, J. Adamski, D. Busch, M.H. de Angelis, M.J. Schmeisser, and S. Windhorst. 2020.

Physiological relevance of the neuronal isoform of inositol-1,4,5-trisphosphate 3-kinases in mice.

Neurosci Lett. 735:135206.

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de Lange, A., U.F. Prodjinotho, H. Tomes, J. Hagen, B.A. Jacobs, K. Smith, W. Horsnell, C. Sikasunge, D. Hockman, M.E. Selkirk, C. Prazeres da Costa, and J.V. Raimondo. 2020.

Taenia larvae possess distinct acetylcholinesterase profiles with implications for host cholinergic signalling.

PLoS Negl Trop Dis. 14:e0008966.

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Demir, E., K. Abdelhai, I.E. Demir, C. Jager, F. Scheufele, S. Schorn, K. Rothe, H. Friess, and G.O. Ceyhan. 2020.

Association of bacteria in pancreatic fistula fluid with complications after pancreatic surgery.

BJS Open. 4:432-437.

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D'Ippolito, E., K.I. Wagner, and D.H. Busch. 2020.

Needle in a Haystack: The Naive Repertoire as a Source of T Cell Receptors for AdoptiveTherapy with Engineered T Cells.

Int J Mol Sci. 21.

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de Los Reyes Jimenez, M., A. Lechner, F. Alessandrini, S. Bohnacker, S. Schindela, A. Trompette, P. Haimerl, D. Thomas, F. Henkel, A. Mourao, A. Geerlof, C.P. da Costa, A.M. Chaker, B. Brune, R. Nusing, P.J. Jakobsson, W.A. Nockher, M.J. Feige, M. Haslbeck, C. Ohnmacht, B.J. Marsland, D. Voehringer, N.L. Harris, C.B. Schmidt-Weber, and J. Esser-von Bieren. 2020.

An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products.

Sci Transl Med. 12.

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Erber, J., S. Weidlich, T. Tschaikowsky, K. Rothe, R.M. Schmid, J. Schneider, and C.D. Spinner. 2020.

Successful bedaquiline-containing antimycobacterial treatment in post-traumatic skin and soft-tissue infection by Mycobacterium fortuitum complex: a case report.

BMC Infect Dis. 20:365.

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Grassmann, S., L. Mihatsch, J. Mir, A. Kazeroonian, R. Rahimi, S. Flommersfeld, K. Schober, I. Hensel, J. Leube, L.O. Pachmayr, L. Kretschmer, Q. Zhang, A. Jolly, M.Z. Chaudhry, M. Schiemann, L. Cicin-Sain, T. Hofer, D.H. Busch, M. Flossdorf, and V.R. Buchholz. 2020.

Early emergence of T central memory precursors programs clonal dominance during chronic viral infection.

Nat Immunol. 21:1563-1573.

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Hamway, Y., K. Taxauer, K. Moonens, V. Neumeyer, W. Fischer, V. Schmitt, B.B. Singer, H. Remaut, M. Gerhard, and R. Mejias-Luque. 2020.

Cysteine Residues in Helicobacter pylori Adhesin HopQ are Required for CEACAM-HopQ Interaction and Subsequent CagA Translocation.

Microorganisms 2020, 8(4), 465;

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Hollandsworth HM, Schmitt V, Amirfakhri S, Filemoni F, Schmidt A, Landström M, Lyndin M, Backert S, Gerhard M, Wennemuth G, Hoffman RM, Singer BB, Bouvet M. 2020.

Fluorophore-conjugated Helicobacter pylori recombinant membrane protein (HopQ) labels primary colon cancer and metastases in orthotopic mouse models by binding CEA-related cell adhesion molecules.

Transl Oncol. 2020 Dec;13(12):100857. doi: 10.1016/j.tranon.2020.100857. Epub 2020 Aug 28. PMID: 32866936; PMCID: PMC7475271.

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Kalfopoulou, E., and J. Huebner. 2020.

Advances and Prospects in Vaccine Development against Enterococci.

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Kollmus, H., H. Fuchs, C. Lengger, H. Haselimashhadi, M.A. Bogue, M.A. Ostereicher, M. Horsch, T. Adler, J.A. Aguilar-Pimentel, O.V. Amarie,  L. Becker, J. Beckers, J. Calzada-Wack, L. Garrett, W. Hans, S.M. Holter, T. Klein-Rodewald, H. Maier, P. Mayer-Kuckuk, G. Miller, K. Moreth, F. Neff, B. Rathkolb, I. Racz, J. Rozman, N. Spielmann, I. Treise, D.H. Busch, J. Graw, T. Klopstock, E. Wolf, W. Wurst, A.O. Yildirim, J. Mason, A. Torres,  T. Mouse Phenome Database, R. Balling, T. Mehaan, V. Gailus-Durner, K. Schughart, and M. Hrabe de Angelis. 2020.

A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.

Mamm Genome. 31:30-48.

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Kretschmer, L., M. Flossdorf, J. Mir, Y.L. Cho, M. Plambeck, I. Treise, A. Toska, S. Heinzel, M. Schiemann, D.H. Busch, and V.R. Buchholz. 2020.

Differential expansion of T central memory precursor and effector subsets is regulated by division speed.

Nat Commun. 11:113.

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Kuhne, J.F., C. Neudorfl, K. Beushausen, J. Keil, S. Malysheva, F. Wandrer, H. Haller, M. Messerle, C. Blume, M. Neuenhahn, F. Schlott, W. Hammerschmidt, R. Zeidler, and C.S. Falk. 2020.

Differential effects of Belatacept on virus-specific memory versus de novo allo-specific T cell responses of kidney transplant recipients and healthy donors.

Transpl Immunol:101291.

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Loffredo-Verde, E., S. Bhattacharjee, A. Malo, J. Festag, A.D. Kosinska, M. Ringelhan, S. Rim Sarkar, K. Steiger, M. Heikenwaelder, U. Protzer, and C.U. Prazeres da Costa. 2020.

Dynamic, Helminth-Induced Immune Modulation Influences the Outcome of Acute and Chronic Hepatitis B Virus Infection.

J Infect Dis. 221:1448-1461.

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Lucienne, M., J.A. Aguilar-Pimentel, O.V. Amarie, L. Becker, J. Calzada-Wack, P. da Silva-Buttkus, L. Garrett, S.M. Holter, P. Mayer-Kuckuk, B. Rathkolb, J. Rozman, N. Spielmann, I. Treise, D.H. Busch, T. Klopstock, C. Schmidt-Weber, E. Wolf, W. Wurst, M. Forny,  D. Mathis, R. Fingerhut, D.S. Froese, V. Gailus-Durner, H. Fuchs, M.H. de Angelis, and M.R. Baumgartner. 2020.

In-depth phenotyping reveals common and novel disease symptoms in a hemizygous knock-in mouse model (Mut-ko/ki) of mut-type methylmalonic aciduria.

Biochim Biophys Acta Mol Basis Dis. 1866:165622.

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Marquez Romero, S., F. Hettler, R. Hausinger, C. Schreck, T. Landspersky, L. Henkel, C. Angerpointner, I.E. Demir, M. Schiemann, F. Bassermann, K.S. Gotze, R. Istvanffy, and R.A.J. Oostendorp. 2020.

Secreted factors from mouse embryonic fibroblasts maintain repopulating function of single cultured hematopoietic stem cells.


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Mishra, K., M. Stankevych, J.P. Fuenzalida-Werner, S. Grassmann, V. Gujrati, Y. Huang, U. Klemm, V.R. Buchholz, V. Ntziachristos, and A.C. Stiel. 2020.

Multiplexed whole-animal imaging with reversibly switchable optoacoustic proteins.

Sci Adv. 6:eaaz6293.

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Muller, T.R., C. Schuler, M. Hammel, A. Kohler, S. Jutz, J. Leitner, K. Schober, D.H. Busch, and P. Steinberger. 2020.

A T-cell reporter platform for high-throughput and reliable investigation of TCR function and biology.

Clin Transl Immunology. 9:e1216.

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Panning, M., J. Wiener, K. Rothe, J. Schneider, M.W. Pletz, G. Rohde, J. Rupp, M. Witzenrath, C.D. Spinner, and C.s.g. Members of the. 2020.

No SARS-CoV-2 detection in the German CAPNETZ cohort of community acquired pneumonia before COVID-19 peak in March 2020.

Infection. 48:971-974

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Pinto-Sietsma, S.J., M. Flossdorf, V.R. Buchholz, J. Offerhaus, H. Bleijendaal, M. Beudel, P.G.A. Volders, R.M.A. Ter Bekke, T. Dormans, P.P. Zwetsloot, P. de Jager, S. Massberg, P. Ramer, C. Wendtner, E. Hoffmann, K. Rothe, S. Feihl, T. Kessler, Y.M. Pinto, and H. Schunkert. 2020.

Antihypertensive drugs in COVID-19 infection.

Eur Heart J Cardiovasc Pharmacother. 6:415-416.

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Poltorak, M.P., P. Graef, C. Tschulik, M. Wagner, V. Cletiu, S. Dreher, B. Borjan, S.P. Fraessle, M. Effenberger, M. Turk, D.H. Busch, J. Plitzko, D.G. Kugler, S. Ragan, T. Schmidt, C. Stemberger, and L. Germeroth. 2020.

Expamers: a new technology to control T cell activation.

Sci Rep. 10:17832.

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Poschke, I.C., J.C. Hassel, A. Rodriguez-Ehrenfried, K.A.M. Lindner, I. Heras-Murillo, L.M. Appel, J. Lehmann, T. Lovgren, S.L. Wickstrom, C. Lauenstein, J. Roth, A.K. Konig, J. Haanen, J. van den Berg, R. Kiessling, F. Bergmann, M. Flossdorf, O. Strobel, and R. Offringa. 2020.

The Outcome of Ex Vivo TIL Expansion Is Highly Influenced by Spatial Heterogeneity of the Tumor T-Cell Repertoire and Differences in Intrinsic In Vitro Growth Capacity between T-Cell Clones.

Clin Cancer Res. 26:4289-4301.

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Prodjinotho, U.F., J. Lema, M. Lacorcia, V. Schmidt, N. Vejzagic, C. Sikasunge, B. Ngowi, A.S. Winkler, and C. Prazeres da Costa. 2020.

Host immune responses during Taenia solium Neurocysticercosis infection and treatment.

PLoS Negl Trop Dis. 14:e0008005.

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Rothe, K., J. Katchanov, J. Schneider, C.D. Spinner, V. Phillip, D.H. Busch,  D. Tappe, R. Braren, R.M. Schmid, and J. Slotta-Huspenina. 2020.

Strongyloides stercoralis hyperinfection syndrome presenting as mechanical ileus after short-course oral steroids for chronic obstructive pulmonary disease (COPD) exacerbation.

Parasitol Int. 76:102087.

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Rothe, K., C.D. Spinner, B. Waschulzik, C. Janke, J. Schneider, H. Schneider, K. Braitsch, C. Smith, R.M. Schmid, D.H. Busch, and J. Katchanov. 2020.

A diagnostic algorithm for detection of urinary tract infections in hospitalized patients with bacteriuria: The "Triple F" approach supported by Procalcitonin and paired blood and urine cultures.

PLoS One. 15:e0240981.

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Schober, K., P. Fuchs, J. Mir, M. Hammel, L. Fanchi, M. Flossdorf, and D.H. Busch. 2020.

The CMV-Specific CD8(+) T Cell Response Is Dominated by Supra-Public Clonotypes with High Generation Probabilities.

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Schober, K., T.R. Muller, and D.H. Busch. 2020.

Orthotopic T-Cell Receptor Replacement-An "Enabler" for TCR-Based Therapies.

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Schober, K., M. Sambucci, G.E. Patzer, and F. Laudisi. 2020.

Young immunologists of Europe, unite!

Eur J Immunol. 50:480-483.

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Schober, K., F. Voit, S. Grassmann, T.R. Muller, J. Eggert, S. Jarosch, B. Weissbrich, P. Hoffmann, L. Borkner, E. Nio, L. Fanchi, C.R. Clouser, A. Radhakrishnan, L. Mihatsch, P. Luckemeier, J. Leube, G. Dossinger, L. Klein, M. Neuenhahn, J.D. Oduro, L. Cicin-Sain, V.R. Buchholz, and D.H. Busch. 2020.

Reverse TCR repertoire evolution toward dominant  low-affinity clones during chronic CMV infection.

Nat Immunol. 21:434-441.

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Schober, S.J., M. Thiede, H. Gassmann, C. Prexler, B. Xue, D. Schirmer, D. Wohlleber, S. Stein, T.G.P. Grunewald, D.H. Busch, G.H.S. Richter, S.E.G. Burdach, and U. Thiel. 2020.

MHC Class I-Restricted TCR-Transgenic CD4(+) T Cells Against STEAP1 Mediate Local Tumor Control of Ewing Sarcoma In Vivo.

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Schuierer, L., M. Gebhard, H.G. Ruf, U. Jaschinski, T.M. Berghaus, M. Wittmann, G. Braun, D.H. Busch, and R. Hoffmann. 2020.

Impact of acyclovir use on survival of patients with ventilator-associated  pneumonia and high load herpes simplex virus replication.

Crit Care. 24:12.

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Softley, C.A., K.M. Zak, M.J. Bostock, R. Fino, R.X. Zhou, M. Kolonko, R. Mejdi-Nitiu, H. Meyer, M. Sattler, and G.M. Popowicz. 2020.

Structure and molecular recognition mechanism of IMP-13 metallo-beta-lactamase. 

Antimicrob Agents Chemother 64(6), DOI:

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Solbach, P., P. Chhatwal, S. Woltemate, E. Tacconelli, M. Buhl, I.B. Autenrieth, M. Vehreschild, N. Jazmati, M. Gerhard, C.K. Stein-Thoeringer, J. Rupp, K. Ulm, A. Ott, F. Lasch, A. Koch, M.P. Manns, S. Suerbaum, and O. Bachmann. 2020.

Microbiota-associated risk factors for C. difficile acquisition in hospitalized patients: A prospective, multicentric study.

Stenger, D., T.A. Stief, T. Kaeuferle, S. Willier, F. Rataj, K. Schober, B. Vick,  R. Lotfi, B. Wagner, T.G.P. Grunewald, S. Kobold, D.H. Busch, I. Jeremias,  F. Blaeschke, and T. Feuchtinger. 2020.

Endogenous TCR promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated TCR knockout CAR.

Blood. 136:1407-1418.

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Wantia, N., S.G. Gatermann, K. Rothe, and R. Laufenberg. 2020.

New EUCAST definitions of S, I and R from 2019 - German physicians are largely not aware of the changes.

Infection. 48:597-606.

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