Light and shade of TCR promiscuity

High-quality multiplexed staining of FFPE colon tissues with ChipCytometry

Adaptive T-cell responses arise from a polyclonal repertoire of naïve precursor cells. However, T-cell therapy in the context of TCR engineering usually comprises a single TCR for disease treatment. The combination of several T-cell clonotypes with different avidities and different landscapes of cross-reactivity against related targets provides flexibility in the immune response and can enhance protective capacity. Enabling polyclonality in immune responses is important in effective vaccination strategies.